Instructions for the use of dimephosphone, price, reviews, analogues. Means "Dimephosphon"

Dimephosphone includes dimethyloxobutylphosphonyl dimethylate as an active substance. The solution also contains purified water.

Release form

The medicine is sold in the form of a solution and a liquid substance.

pharmachologic effect

Dimephosphon is an antiacidemic drug that improves acid-base balance (acid-base state) at.

Pharmacodynamics and pharmacokinetics

In addition to the normalization of acid-base balance with acidosis this drug enhances the reabsorption of bicarbonates, lung ventilation , as well as processes acido - and ammoniogenesis in the kidneys.

The drug has membrane stabilizing , antioxidant and anti-inflammatory properties. It improves blood flow and metabolism in the brain tissues, promotes the regulation of blood circulation, reduces cardiac and pulmonary insufficiency , strengthens the protective functions of the skin and mucous membranes.

Main antiacidotic the effect of the drug is due pulmonary intensification and renal mechanisms regulation of acid-base balance. In addition, the effect is increased blood flow and tissue metabolism, as well as a decrease in the level pyruvic and lactic acid in brain tissues.

The drug helps to stabilize cell membranes, improves brain activity and helps to normalize sleep. He also restores reactivity brain and reflexes, the arcs of which are closed through the stem sections, reduces the severity pyramidal , vestibular , auditory , cerebellar and visual disorders .

The antioxidant effect is due to the fact that Dimephosphon prevents the activation peroxidation lipids, and also increases the activity antioxidant in brain tissues.

It also contributes to the activation of energy processes through its effect on mitochondria and stimulation pituitary-thyroid system . Thus, tissues consume more thyroid , and energy and catabolic processes in mitochondria are activated.

Can be used when cerebrovascular insufficiency in various forms, as it improves microcirculation and increases the resistance of nerve cells to.

After one application, the drug easily penetrates through histohematic barriers . The maximum concentration is reached in 1 hour. The active substance is distributed to many organs and tissues.

The drug is excreted mainly in the urine unchanged.

Indications for the use of Dimephosphone

Indications for the use of Dimephosphone are as follows:

• subcompensated hypertension in the pulmonary circulation;
• acidosis in case of occurrence pneumonia , chronic lung diseases, as well as after operations;
• transient ischemic attacks ;
• diseases of ENT organs;
• ischemic and hemorrhagic ;
• myelopathy ;
• radiculopathy ;
• TBI ;
• dental diseases;
• rickets-like diseases in childhood;
• chronic ;
• brain and spinal cord injuries neurosurgical operating rooms );
• syndrome and Meniere's disease ;
• in children;
• autonomic lability ;
• hereditary entero-oxaluric syndrome ;
• infectious and inflammatory diseases of the skin and mucous membranes;
• trophic ulcers ;
• mucositis at malignant neoplasms ;
• discirculatory ;
• infected skin lesions.

Contraindications

• chronic (I-II degree);

Children under 18 years of age should not be given the drug TBI , circulatory disorders in the brain, chronic nonspecific lung diseases, planned neurosurgical operations , scattered , consequences ischemic and hemorrhagic strokes , chronic cerebrovascular insufficiency (provoked and hypertension ), Meniere's disease . For children under 12 years of age, the drug is contraindicated in case of parasympathetic type .

Side effects

The following adverse reactions are possible: nausea, vomiting (if used orally), impaired concentration. As a rule, all undesirable manifestations pass quickly and do not require special treatment.

If some irritation occurs during external use, it is desirable to reduce the concentration of the solution by 2 times.

Application instruction of Dimephosphon (Way and dosage)

The drug is applied orally 1-4 times a day at an average of 30-50 mg / kg. Because of the bitter taste, you can drink milk, sweet tea or fruit juice. The treatment regimen, depending on the disease, may be as follows:

• TBI – 3-8 weeks;
• cerebrovascular accident , Meniere's syndrome – 1-4 weeks;
• exacerbation prevention hay fever – 3 weeks (before the expected onset of seasonal deterioration and during the flowering of the plant causing allergy );
• neurosurgical operations - for five days before surgery and about 10-14 days after;
• autonomic dysfunction , acidosis , diseases of the respiratory system , as well as atopic (in childhood) - 2-4 weeks.

Instructions for use Dimephosphon externally reports that the drug is used in the form of lotions, dressings and turundas with a solution. In the case of infectious and inflammatory allergic reactions on the skin and mucous membranes, procedures are done every day for 3-14 days. During complex treatment acne the affected areas of the skin should be wiped with a solution during the day 3-4 times, and in the evening make lotions. At erysipelas the affected area is lubricated 3 times every day for 3-5 days. And for the purpose of prevention radiation mucositis 20 minutes before the exposure of the dose, gauze napkins with the solution are placed in the projection of the radiation beams.

Intravenously drug can be used jet or drip . Application instruction of Dimefosfon jet provides for the following scheme: 1-2 ampoules with medicine are diluted in approximately 15 ml of pure water intended for injections , or 15 ml of a 0.9% solution. For application drip the drug is diluted in 200-400 ml of a solution of 0.9% sodium chloride. Dimephosphone should be administered 1-4 times a day for 7-10 days.

Overdose

In case of an overdose of the drug, the severity dose-dependent adverse reactions increase. As a therapy, gastric lavage , and reception . Treatment is symptomatic.

Interaction

Significant drug interactions with other drugs have not been established.

Terms of sale

The medicine is sold by prescription only.

Storage conditions

Store this medicine at room temperature in a dark place.

Best before date

You can not use the drug after the expiration date indicated on the package. The maximum shelf life is 3 years.

Dimephosphone is a synthetic drug whose action is aimed at normalizing the acid-base environment. Produced in the form of a concentrate for the preparation of a solution for external and internal use.

Pharmacological action of Dimephosphone

The active substance in the preparation is dimethyloxobutylphosphonyl dimethylate. The auxiliary substance is purified water.

According to the instructions, Dimephosphone is an antiacidemic agent. The drug contributes to the normalization of acid-base balance in acidosis of various origins by stimulating the metabolic processes of its regulation, especially pulmonary and renal. The drug also enhances internal blood flow and metabolic processes in body tissues.

Dimephosphone has a vasodilatory effect on the vessels of the brain, as well as nootropic, anti-edematous, antidepressant, anti-ischemic, mnemotropic, stress-protective, anti-amnestic actions.

The instructions for Dimephosphon indicate that it acts as a powerful antiallergic, immunomodulatory, membrane stabilizing, antihypoxic, radioprotective and antimutagenic agent. The drug also has a positive effect on tissue regeneration and inhibits the process of platelet aggregation.

The drug dose-dependently reduces the intensity of lipid peroxidation, contributes to the inhibition of spontaneous and ADP-induced aggregation, while increasing the antioxidant activity of platelets and reducing the content of lipid peroxidation products in them.

According to reviews of Dimephosphone, the drug normalizes cerebral circulation, vascular tone and blood supply to the brain, and also improves venous outflow.

The cerebroprotective property and neurotropic activity of the drug are carried out due to its effect on the mechanisms of cerebral neurometabolic protection. Dimephosphone normalizes energy and carbohydrate metabolism, blunts the process of activation of lipid peroxidation and increases the activity of antioxidant enzymes contained in brain tissues. In case of traumatic brain injury, it promotes its metabolism and electrical activity, eliminates the development of vasomotor cephalgia, reduces the level of oxygen consumption by brain tissues, prevents respiratory and heart failure of central origin, and affects the regression of stem and focal hemispheric symptoms.

In reviews of Dimephosphone, it is noted that this drug eliminates allergic inflammation, manifestations of atopic bronchial asthma and dermatitis.

When prescribing Dimephosphon to children in combination with cholestyramine, enzymes and vitamins, a dulling of the progression of hereditary entero-oxaluric syndrome is observed.

When applied topically, the drug improves the protective functions of the skin and its mucous membranes, and also has an antiseptic effect.

Indications for the use of Dimephosphone

The instructions for Dimephosphon indicate that the drug is intended for internal and external use.

Inside the medicine is prescribed for such diseases and conditions as:

• Traumatic brain injury;
• Violations of cerebral circulation;
• Neurosurgical operations;
• Consequences of hemorrhagic and ischemic stroke;
• Osteochondrosis;
• Chronic lung diseases with signs of pulmonary heart and respiratory failure;
• Vegetovascular dystonia;
• Migraine;
• Cerebrovascular insufficiency (as a consequence of hypertension and atherosclerosis);
• Meniere's disease;
• Acidosis;
• Respiratory diseases;
• Pollinosis;
• Atopic bronchial asthma.

Outwardly, Dimephosphon is recommended to be taken for various infectious, inflammatory and allergic lesions of the mucous membranes and skin, for the treatment of wounds at the suture sites and the exit of Ilizarov's spokes. The drug is actively used in dermatology for the treatment of skin with acne and seborrhea.

Methods of using Dimephosphon and dosage

Orally, the medicine is taken after a meal with a small amount of clean water. When prescribing Dimephosphon to children, it is recommended to drink the drug with milk, juice or tea because of the bitter taste of the medicine.

The duration of therapy depends on the complexity of the disease and lasts from 3 days to 2 months.

In acute and chronic disorders of craniocerebral circulation, brain injuries, stroke, Meniere's disease, Migraine, adults are prescribed 1 tbsp. spoons of Dimephosphone 3-4 times a day. The duration of the course is 3 weeks.

During neurosurgical operations, you should take 1 tbsp. spoon for 5 days before surgery and 2 months after.

For the treatment of osteochondrosis, a dose of 1 des. spoons 4 times a day. The duration of therapy is 3 weeks.

With vegetovascular dystonia, Dimephosphone is taken by children over 12 years old and adults, 1 tbsp. spoon 3 times a day. The duration of treatment is 3 weeks.

Outwardly, the drug is used daily in the form of dressings, lotions and turundas with a solution. The course of treatment is from 3 to 14 days.

In order to heal the area of ​​the seams and the entry points of the Ilizarov wires, gauze napkins soaked in Dimephosphone should be applied for 14 days.

Contraindications for use

The instructions for Dimephosphon noted that the use of the drug is not recommended in the presence of diseases such as chronic renal failure, epilepsy.

Also, contraindications to this drug are the age of children under 12 years of age in the presence of vegetovascular dystonia, as well as the age of up to 18 years of age if acute clinical cerebrovascular accidents, traumatic brain injuries, osteochondrosis, multiple sclerosis, migraine and Meniere's disease are diagnosed in children.

Side effects of Dimephosphone

In reviews of Dimephosphone, it is reported that the use of the drug can cause the manifestation of various dyspeptic phenomena.

During treatment with Dimephosphon, concentration of attention may worsen in children, and drowsiness sometimes appears.

Overdose

When using the drug in amounts exceeding those recommended, according to reviews of Dimephosphone, there may be an increase in the manifestations of dose-dependent side effects.

Additional Information

It is necessary to store Dimephosphon in a dry, dark, cool place and out of the reach of children. Shelf life - 4 years.

The drug affects the ability to drive heavy machinery and vehicles.

The drug "Dimephosphone", the price of which is within 300 rubles, refers to membrane-stabilizing, immunomodulating, anti-inflammatory drugs. The drug has radioprotective and antihypoxic activity. The drug exhibits an antioxidant effect, dose-dependently reduces the severity of lipid peroxidation. Due to the activation of metabolic mechanisms, the acid-base state is normalized, there is an increase in tissue metabolism and intraorganic blood flow. The drug "Dimephosphone" (reviews of experts confirm this) has some neuropharmacological properties.

So, the agent has a nootropic, antiamnestic and antidepressant effect, it is distinguished by an antiischemic, mnemotropic, stress-protective effect. Thanks to the action of the drug "Dimephosphon" (instructions for use contains such data), cerebral circulation, venous outflow are improved, blood filling of the brain and tone in the cerebral vessels are normalized. Neurotropic effects and cerebroprotective activity are determined by the effect on the neurometabolic brain. Energy and carbohydrate metabolism is normalized, the activity of antioxidant enzymes in the brain tissue increases, and the development of lipid peroxidation is prevented. The maximum level in the blood is observed 2-3 hours after taking the medicine.

Means "Dimephosphon". Instructions for use. Indications

The drug is prescribed for disorders in cerebral circulation associated with hypertension, atherosclerosis, pathologies of the spine, vasomotor dystonia. The indications, in particular, include radiculopathy, myelopathy, dyscirculatory encephalopathy, the consequences of previous and ischemic strokes, ischemic attacks of a transient type. The drug "Dimephosphone" instructions for use recommends for head injury, surgical injuries of the spinal cord and brain of a neurosurgical nature, Meniere's disease and syndrome.

The drug is prescribed for chronic and acute pathologies in the respiratory tract, accompanied by pulmonary subcompensated hypertension, acidosis with pneumonia, bronchospastic variant of bronchial obstruction (pulmonary tuberculosis, bronchial asthma, chronic bronchitis). Indications include atopic dermatitis, pathologies in the ENT organs, rickets-like diseases in children, trophic-type ulcers, infected wounds, acute respiratory viral lesions, hereditary entero-oxaluric syndrome.

The medicine "Dimephosphon". Instructions for use

The drug is prescribed intravenously. The contents of 1-2 ampoules are diluted in 10-20 ml of water (sterile) for injection or sodium chloride solution 0.9%. For drip administration, the drug is dissolved in 200-400 ml of sodium chloride 0.9%. Injections are carried out 1-4 times a day for seven or ten days. Inside the medicine is recommended at 30-50 mg / kg no more than four times a day. The duration of therapy against the background in children, pathologies in the respiratory organs and with acidosis, with autonomic dysfunction, and circulatory disorders - from one to four weeks, with TBI - from three weeks to two months.

Dimephosphone is an antiacidemic agent that normalizes blood flow and metabolism of brain tissues and acid-base balance in acidosis of various etiologies, reduces pulmonary and heart failure, and improves the regulation of blood circulation, including cerebral. When applied topically, the drug has an antiseptic effect.

Release form and composition

Dosage forms of Dimephosphone - 15% solution for oral and external use, as well as a concentrate for preparing a solution for injection.

The active substance of the drug is dimethyloxobutylphosphonyl dimethylate. In 100 ml of solution it contains 15 grams. Purified water is used as an auxiliary component.

1 ml of concentrate contains 1 gram of dimethyloxobutylphosphonyl dimethylate.

Dimephosphone solution is sold in 100 ml glass bottles, concentrate - in 1 ml ampoules.

Indications for use

According to the instructions for Dimephosphone, the drug is used for:

• Acidosis caused by diabetes mellitus, SARS, chronic lung diseases, pneumonia;
• Acidosis in the postoperative period;
• Pollinosis in children;
• Myelopathy and radiculopathy;
• Bronchospastic variant of bronchial obstruction, including chronic bronchitis, bronchial asthma, incl. atopic bronchial asthma in children;
• Dyscirculatory encephalopathy, incl. developed against the background of arterial hypertension;
• Subcompensated hypertension in the pulmonary circulation;
• Atopic dermatitis;
• Rickets-like diseases in children;
• Mucositis developed as a result of radiation therapy for malignant neoplasms;
• Transient ischemic attacks, ischemic and hemorrhagic stroke (at the initial stages of the disease; with complications after a previous stroke);
• Syndrome and Meniere's disease;
• Vegetative lability;
• Infected wounds and trophic ulcers;
• Hereditary entero-oxaluric syndrome;
• Traumatic brain injuries (concussion and bruise of the brain);
• Neurosurgical surgical injuries of the brain and spinal cord;
• Diseases of the ENT organs;
• dental diseases;
• Infectious and inflammatory diseases of the skin and mucous membranes, including acne, erysipelas, as well as purulent-inflammatory complications at the exit points of the spokes of the Ilizarov apparatus.

Contraindications

The use of Dimephosphone is contraindicated in:

• Hypersensitivity to dimethyloxobutylphosphonyl dimethylate;
• epilepsy;
• Chronic renal failure II and III stages.

Method of application and dosage

According to the instructions for Dimephosphon, the dosage of a 15% oral solution is determined at the rate of 30-50 mg per kilogram of weight. Take the drug, depending on the doctor's prescription, from 1 to 4 times a day. The solution has a bitter taste, so children can be given to drink it with sweet tea, milk or fruit juice.

Duration of Dimephosphon use:

• With Meniere's syndrome and disorders of cerebral circulation - 1-4 weeks;
• With autonomic dysfunction, atopic bronchial asthma in children, acidosis and respiratory diseases - 2-4 weeks;
• With craniocerebral injuries - from 3 to 8 weeks;
• When carrying out planned neurosurgical interventions - 5 days before surgery and 10-14 after;
• With hay fever for the prevention of exacerbation - starting 3 weeks before the expected seasonal deterioration and throughout the entire flowering period of the allergen plant.

External use of Dimephosphone:

• In infectious-inflammatory-allergic diseases of the mucous membranes and skin - in the form of lotions, turundas and dressings with a 15% solution daily for 3-14 days;
• In order to prevent the development of radiation mucositis, gauze wipes soaked in a solution are placed in the projection of radiation beams approximately 20 minutes before the dose is exposed;
• In case of acne, the solution should wipe the skin 3-4 times a day, and in the evening make additional lotions;
• With erysipelas - lubricate the affected areas three times a day.

A solution for intravenous infusion is prepared from Dimephosphone concentrate:

• For jet administration, the contents of 1-2 ampoules are diluted, respectively, in 10 or 20 ml of sterile injection water or 0.9% sodium chloride solution;
• For drip administration, the contents of 1-2 ampoules are diluted in 200-400 ml of 0.9% NaCl solution.

Enter the drug 1-4 times a day. Treatment usually lasts 7 to 10 days.

Side effects

In the vast majority of cases, Dimephosphone, according to patient reviews, is well tolerated.

When ingested, diarrhea, heartburn, nausea, and vomiting are sometimes noted.

At the beginning of treatment, some patients experience increased drowsiness and a deterioration in the ability to concentrate.

special instructions

When applied to mucous membranes, Dimephosphone can cause irritation, in which case the solution can be diluted with water (twice).

The drug can cause drowsiness and impair the ability to concentrate, especially at the beginning of treatment, therefore, in the first days of using Dimephosphon, it is recommended to refrain from potentially hazardous activities and driving a car.

Analogues

Dimephosphone has no structural analogues. In this or that case, the doctor may prescribe one of the following drugs: Actinogyal, Homeovox, Carmolis, Kokkulin, Laprot, Ronidaza, Ingafitol, Lidaza, Longidaza, Mucosa compositum, Pulsatilla compositum, Strumel T, Ceruloplasmin, Cystamin, Ubiquinone compositum, Schwef-Hel , Mardil Selen, Neovasculgen.

Terms and conditions of storage

Dimephosphon belongs to a group of drugs sold in pharmacies by prescription.

Store the medicinal product, according to the instructions, in a dark place at temperatures up to 25 ºС. Shelf life - 3 years.

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Dimephosphone is a synthetic drug that normalizes the acid-base environment caused mainly by acute respiratory and infectious diseases.

Widely used in pediatrics.

pharmachologic effect

Antiacidemic agent. It is used in the treatment of acute respiratory and other infectious diseases, diabetes mellitus, rickets-like diseases that cause acid-base balance disorders. Dimephosphon has antiseptic, immunomodulatory, antiischemic, membrane stabilizing, antiamnestic, antidepressant, antiallergic, antiedematous and stress-protective effects.

When applied externally, it has an antiseptic effect, increasing the protective functions of the skin and mucous membranes. With traumatic brain injuries, it has a beneficial effect on tissue metabolism and electrical activity.

The active substance of Dimephosphone is dimethyloxobutylphosphonyl dimethylate.

Release form

Dimephosphone is produced as a solution (colorless transparent liquid) for internal and external use. 100 ml of the solution contains 15 mg of dimethyloxobutylphosphonyl dimethylate and the excipient is water. In orange glass bottles of 100 ml.

Indications for use

The drug is effective in the treatment of a wide range of diseases.

According to the instructions, Dimephosphone is used as part of complex therapy for:

• acidosis;
• Acute and chronic disorders of cerebral circulation;
• Respiratory diseases and respiratory failure in infectious and inflammatory diseases (influenza, SARS, pneumonia, tuberculosis);
• Traumatic brain injuries;
• Osteochondrosis;
• Vegetative-vascular dystonia of the parasympathetic type;
• multiple sclerosis;
• Migraine;
• Meniere's disease;
• Planned neurosurgical operations;
• Atopic bronchial asthma;
• Consequences of ischemic and hemorrhagic strokes;
• Pollinose.

Outwardly Dimephosphone is used to treat:

• Trophic ulcers;
• Traumatic disorders of the skin and soft tissues;
• Erysipelas;
• Burns.

Dimephosphone is also used as a prophylaxis of purulent-inflammatory complications in traumatology at the exit points of the spokes of the Ilizarov apparatus.

Contraindications

According to the instructions, Dimephosphone is contraindicated in epilepsy, increased convulsive readiness and renal failure of 2-3 degrees.

The drug is also not used for hypersensitivity to the active substance.

Application instruction of Dimefosfon

Dimephosphone can be used orally, topically, or as an intravenous injection. The dose of the drug is calculated the same for children and adults based on body weight.

When taken orally as a solution - 30-50 mg per 5 kg of body weight. Apply after meals, usually with water.

The drug is taken 1-4 times a day. The duration of treatment depends on the disease:

• With acidosis, respiratory diseases, disorders of cerebral circulation and bronchial asthma, children are prescribed from one to four weeks. According to reviews after Dimephosphon, improvement in children occurs quite quickly;
• When carrying out neurosurgical operations, the drug is used for 5 days before the operation and 10-14 after it;
• With craniocerebral injuries, the course is longer, usually from 3 weeks to 2 months;
• To prevent exacerbation of hay fever, Dimephosphone is used for children and adults before the expected exacerbation and does not stop taking throughout the entire period of pollination of plants.

According to the instructions, Dimephosphone is used externally in the form of lotions, dressings or turundas for skin diseases of allergic and infectious-inflammatory origin or for inflammation of the mucous membranes. The drug is used until the disappearance of clinical manifestations.

Dimephosphone is used intravenously 1-4 times a day for 7-10 days:

• Jet. The contents of 1-2 ampoules are diluted with water for injection or 0.9% sodium chloride solution (10-20 ml);
• Drip. The contents of 1-2 ampoules are diluted with 0.9% sodium chloride solution (200-400 ml).

According to reviews, Dimephosphone at the beginning of treatment can cause drowsiness and indigestion. During this period, you need to drive vehicles with caution. With an overdose, the side effects increase. In this case, activated charcoal, symptomatic therapy and gastric lavage are used.

Storage conditions

Dimephosphone is available by prescription. Shelf life - 3 years.

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